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Figure 5: Comparison of MR and histologic findings in a mouse that still had considerable femoral artery damage after 10 days. A, T2 (0–60 msec), B, 
3 ([0–2.1] x 10–3 mm2/sec), and, C, FA (0.1–0.7) maps, and, D, clustered MR image based on 3, FA, and T2 values are shown. Red represents high diffusivity; blue, high T2; and light blue, the highest T2. E, Histologic specimen from the same limb at an approximately corresponding cross section. For display purposes, the red and blue channels of the red/green/blue image (E) were enhanced (with image-processing tools) relative to the green channel. F, Histologic specimen from central region of tibialis anterior (area outlined by dotted-line rectangle in E) has high ADC and swollen cells. The locations of the blue regions in D are similar to the locations of the blue areas in E. G, Histologic specimen from the gastrocnemius (area outlined by solid-line rectangle in E) has high T2 and multiple inflammatory cells and collagen. Other mice had similar corresponding clustered image and histologic findings. (Gomori trichrome stain; original magnification, x40.)
