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Figure 6: Graph shows IL-1 and IL-6 production of labeled monocytes 24 hours after incubation with SPIOs at a concentration of 1.0 mg Fe/mL. Freshly isolated monocytes (Ctrl) served as negative control. Monocytes stimulated with lipopolysaccharide (LPS) for 24 hours served as a positive control. Data are presented as mean ± standard error of the mean. * = P < .05 versus freshly isolated monocytes.