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© RSNA, 2008
Table E1. Summary of Studies Evaluating Dynamic Contrast-enhanced CT, Dynamic Contrast-enhanced MR Imaging, 18F FDG PET, and 99mTc-depreotide SPECT for Detecting Malignancy in a Solitary Pulmonary Nodule
|
Study |
Year |
Journal |
Origin |
Age (y)* |
Nodule Size (mm)† |
No. of Nodules |
Male/Female Patients (Total)‡ |
Reference Standard |
True Positive |
False Negative |
No. with Disease |
False Positive |
True Negative |
No. without Disease |
Study Design |
|
|
Dynamic contrast-enhanced CT |
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|
Swensen et al (17) |
1992 |
Radiology |
USA |
60 |
6–30 |
30 |
28/24 (52) |
Histology (44) / follow-up (8) |
23 |
0 |
23 |
1 |
6 |
7 |
Retrospective |
|
|
Swensen et al (18) |
1995 |
Radiology |
USA |
63 |
6–40 |
163 |
94/69 (163) |
Histology (132) / follow-up (31) |
111 |
0 |
111 |
12 |
40 |
52 |
Retrospective |
|
|
Yamashita et al (19) |
1995 |
Radiology |
Japan |
52 |
2–30 |
32 |
21/11 (32) |
Histology |
18 |
0 |
18 |
1 |
13 |
14 |
Retrospective |
|
|
Swensen et al (20) |
1996 |
Radiology |
USA |
63 |
7–30 |
107 |
57/50 (107) |
Histology (102) / follow-up (5) |
51 |
1 |
52 |
15 |
40 |
55 |
Retrospective |
|
|
Potente et al (21) |
1997 |
Comput Med Imaging Graph |
Italy |
64 |
5–30 |
25 |
25/15 (40) |
Histology |
17 |
0 |
17 |
2 |
6 |
8 |
Retrospective |
|
|
Zhang et al (22) |
1997 |
Radiology |
Japan |
64 |
5–30 |
65 |
40/25 (65) |
Histology (54) / follow-up (11) |
40 |
2 |
42 |
7 |
16 |
23 |
Retrospective |
|
|
Swensen et al (23) |
2000 |
Radiology |
USA |
64 |
5–40 |
356 |
175/181 (356) |
Histology (237) / follow-up (119) |
167 |
4 |
171 |
78 |
107 |
185 |
Prospective |
|
|
Yi et al (24) |
2004 |
Radiology |
South Korea |
56 |
15 |
198 |
82/49 (131) |
Histology (109) / follow-up (22) |
68 |
1 |
70 |
28 |
33 |
61 |
Retrospective |
|
|
Kim et al (25) |
2004 |
J Comput Assist Tomogr |
South Korea |
50 |
7–38 |
81 |
32/18 (40) |
Histology (51) / follow-up (30) |
17 |
2 |
19 |
10 |
21 |
31 |
Prospective |
|
|
Jeong et al (26) |
2005 |
Radiology |
South Korea |
55 |
<30 |
107 |
62/45 (107) |
Histology (101) / follow-up (6) |
46 |
3 |
49 |
6 |
52 |
58 |
Prospective |
|
|
Dynamic contrast-enhanced MR imaging |
|
|
|
|
|
|
|
|
|
|
|
|
||||
|
Hittmair et al (27) |
1995 |
Magn Reson Imaging |
Austria |
58 |
5-36 |
21 |
11/10 (21) |
Histology |
15 |
0 |
15 |
2 |
4 |
6 |
Prospective |
|
|
Guckel et al (28) |
1996 |
Radiology |
Switzerland |
58 |
10-30 |
28 |
20/8 (28) |
Histology |
20 |
0 |
20 |
0 |
8 |
28 |
Prospective |
|
|
Ohno et al (29) |
2002 |
Radiology |
Japan |
68 |
<30 |
58 |
35/23 (58) |
Histology |
38 |
0 |
38 |
5 |
15 |
20 |
Retrospective |
|
|
Kim et al (25) |
2004 |
J Comput Assist Tomogr |
Korea |
50 |
21 |
81 |
54/27 (81) |
Histology (62) / follow-up (19) |
20 |
1 |
32 |
7 |
26 |
49 |
Prospective |
|
|
Schaefer et al (30) |
2004 |
Radiology |
Germany |
61 |
5-40 |
51 |
11/40 (51) |
Histology (46) / follow-up (5) |
26 |
1 |
27 |
6 |
18 |
24 |
Prospective |
|
|
Tozaki et al (31) |
2005 |
J Comput Assist Tomogr |
Japan |
67 |
21 |
45 |
27/18 (45) |
Histology |
29 |
0 |
29 |
3 |
13 |
16 |
Prospective |
|
|
18F-FDG PET |
|
|||||||||||||||
|
Kubota et al (32) |
1990 |
J Nucl Med |
Japan |
65 |
5-60 |
13 |
31/15 (46) |
Histology / cytology |
4 |
2 |
6 |
1 |
6 |
7 |
Prospective |
|
|
Gupta et al (33) |
1992 |
Radiology |
USA |
71 |
6-60 |
19 |
13/7 (20) |
Histology (19) / follow-up (1) |
12 |
0 |
12 |
0 |
7 |
7 |
Prospective |
|
|
Dewan et al (34) |
1993 |
Chest |
USA |
65 |
6-30 |
31 |
?/? (30) |
Histology (29) / follow-up (1) |
19 |
2 |
21 |
2 |
8 |
10 |
Prospective |
|
|
Patz et al (35) |
1993 |
Radiology |
USA |
60 |
<40 |
38 |
20/31 (51) |
Histology (49) / cytology (1) / follow-up (1) |
25 |
0 |
25 |
0 |
13 |
13 |
Prospective |
|
|
Dewan et al (36) |
1995 |
Chest |
USA |
65 |
10-60 |
22 |
26/7 (33) |
Histology |
16 |
0 |
16 |
1 |
5 |
6 |
Retrospective |
|
|
Duhaylongsod et al (37) |
1995 |
J Thorac Cardiovasc Surg |
USA |
58 |
<40 |
47 |
60/40 (100) |
Histology |
31 |
0 |
31 |
3 |
13 |
16 |
Retrospective |
|
|
Duhaylongsod et al (38) |
1995 |
Ann Thorac Surg |
USA |
61 |
12-45 |
39 |
33/20 (53) |
Histology (52) / follow-up (1) |
21 |
1 |
22 |
2 |
15 |
17 |
Retrospective |
|
|
Gupta et al (39) |
1996 |
J Nucl Med |
USA |
65 |
6-30 |
42 |
45/16 (61) |
Histology (60) / follow-up (1) |
30 |
3 |
33 |
2 |
7 |
9 |
Retrospective |
|
|
Bury et al (40) |
1996 |
Eur Respir J |
Belgium |
64 |
<40 |
50 |
37/13 (50) |
Histology |
33 |
0 |
33 |
2 |
15 |
17 |
Prospective |
|
|
Dewan et al (41) |
1997 |
Chest |
USA |
64 |
<30 |
26 |
?/? (49) |
Histology (48) / follow-up (1) |
17 |
0 |
17 |
0 |
9 |
9 |
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