Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Published online before print June 28, 2002, 10.1148/radiol.2242011382

(Radiology 2002;224:383.)

A more recent version of this article appeared on August 1, 2002
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow All Versions of this Article:
2242011382v1
224/2/383    most recent
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Macari, M.
Right arrow Articles by Megibow, A. J.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Macari, M.
Right arrow Articles by Megibow, A. J.

Gastrointestinal Imaging

Colorectal Neoplasms: Prospective Comparison of Thin-Section Low-Dose Multi–Detector Row CT Colonography and Conventional Colonoscopy for Detection1

Michael Macari, MD, Edmund J. Bini, MD, Xiaonan Xue, PhD, Andrew Milano, MD, Seth S. Katz, MD, PhD, Daniel Resnick, BA, Hersh Chandarana, BS, Glen Krinsky, MD, Klaus Klingenbeck, PhD, Christopher H. Marshall, PhD and Alec J. Megibow, MD, MPH

1 From the Departments of Radiology (M.M., S.S.K., D.R., H.C., G.K., A.J.M.), Medicine (E.J.B., A.M.), Environmental Medicine (X.X.), and Radiation Safety (C.H.M.), New York University Medical Center, Tisch Hospital, 560 First Ave, Suite HW 207, New York, NY 10016; and Siemens Medical Systems, Forcheim, Germany (K.K.). Received August 14, 2001; revision requested September 11; revision received November 8; accepted December 12. Supported in part by a Young Investigator Grant from the Society of Computed Body Tomography/Magnetic Resonance. Supported by the Phillip and Janice Levin Foundation and the Irwin and Marjorie Guttag Foundation. Address correspondence to M.M. (e-mail: michael.macari@med.nyu.edu).

PURPOSE: To prospectively compare thin-section low-dose multi–detector row computed tomographic (CT) colonography with conventional colonoscopy for the detection of colorectal neoplasms.

MATERIALS AND METHODS: One hundred five patients underwent CT colonography immediately before colonoscopy. Supine and prone CT colonographic acquisitions to image the region during a 30-second breath hold were performed. CT colonographic images were prospectively interpreted for the presence, location, size, and morphologic features of polyps. The time of image interpretation was noted. Sensitivity, specificity, and positive and negative predictive values of CT colonography were calculated, with 95% CIs, by using colonoscopic findings as the reference standard. The weighted CT dose index was calculated on the basis of measurements in a standard body phantom. Effective dose was calculated by using commercially available software.

RESULTS: Median CT data interpretation time was 12 minutes. One hundred thirty-two polyps in 59 patients were identified at colonoscopy; no polyps were detected in 46 patients. Sensitivities for detection of polyps smaller than 5 mm, 6–9 mm, and larger than 10 mm in diameter were 12% (11 of 91 polyps), 70% (19 of 27 polyps), and 93% (13 of 14 polyps), respectively. Estimated overall specificity was 97.7% (515 of 527 imaging results). The total weighted CT dose index for combined supine and prone CT colonography was 11.4 mGy. The effective doses for combined CT colonography were 5.0 mSv and 7.8 mSv for men and women, respectively.

CONCLUSION: Low-dose multi–detector row CT colonography has excellent sensitivity and specificity for detection of colorectal neoplasms 10 mm and larger.

© RSNA, 2002

Index terms: Colon, CT, 75.12111, 75.12117, 75.12118 • Colon neoplasms, 75.311 • Colon neoplasms, CT, 75.12111, 75.12117, 75.12118 • Colonoscopy, 75.1289 • Computed tomography (CT), comparative studies, 75.12111, 75.12117, 75.12118




This article has been cited by other articles:


Home page
 GutHome page
J K Turner and J Green
Iron deficiency anaemia guidelines: time for an update?
Gut, September 1, 2008; 57(9): 1330 - 1331.
[Full Text] [PDF]

Home page
 RadiologyHome page
S. H. Kim, J. M. Lee, C.-I. Shin, H. C. Kim, J.-G. Lee, J. H. Kim, J. Y. Choi, H. W. Eun, J. K. Han, J. Y. Lee, et al.
Effects of Spatial Resolution and Tube Current on Computer-aided Detection of Polyps on CT Colonographic Images: Phantom Study
Radiology, August 1, 2008; 248(2): 492 - 503.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
E J HALL and D J BRENNER
Cancer risks from diagnostic radiology
Br. J. Radiol., May 1, 2008; 81(965): 362 - 378.
[Abstract] [Full Text] [PDF]

Home page
 CA Cancer J ClinHome page
B. Levin, D. A. Lieberman, B. McFarland, R. A. Smith, D. Brooks, K. S. Andrews, C. Dash, F. M. Giardiello, S. Glick, T. R. Levin, et al.
Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps, 2008: A Joint Guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology
CA Cancer J Clin, May 1, 2008; 58(3): 130 - 160.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
J. Sosna, T. Sella, O. Sy, P. T. Lavin, R. Eliahou, S. Fraifeld, and E. Libson
Critical Analysis of the Performance of Double-Contrast Barium Enema for Detecting Colorectal Polyps >= 6 mm in the Era of CT Colonography
Am. J. Roentgenol., February 1, 2008; 190(2): 374 - 385.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
D. J. M. Tolan, E. M. Armstrong, and A. H. Chapman
Replacing Barium Enema with CT Colonography in Patients Older Than 70 Years: The Importance of Detecting Extracolonic Abnormalities
Am. J. Roentgenol., November 1, 2007; 189(5): 1104 - 1111.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
L. Copel, J. Sosna, J. B. Kruskal, V. Raptopoulos, R. J. Farrell, and M. M. Morrin
CT Colonography in 546 Patients with Incomplete Colonoscopy
Radiology, August 1, 2007; 244(2): 471 - 478.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
S. H. Park, E. K. Choi, S. S. Lee, J.-S. Byeon, J.-Y. Jo, Y. H. Kim, K. H. Lee, H. K. Ha, and J. K. Han
Polyp Measurement Reliability, Accuracy, and Discrepancy: Optical Colonoscopy versus CT Colonography with Pig Colonic Specimens
Radiology, July 1, 2007; 244(1): 157 - 164.
[Abstract] [Full Text] [PDF]

Home page
 SURG INNOVHome page
C. Torres, S. Szomstein, and S. D. Wexner
Virtual Colonoscopy in Colorectal Cancer Screening
Surgical Innovation, March 1, 2007; 14(1): 27 - 34.
[Abstract] [PDF]

Home page
 RadioGraphicsHome page
T. Mang, A. Maier, C. Plank, C. Mueller-Mang, C. Herold, and W. Schima
Pitfalls in Multi-Detector Row CT Colonography: A Systematic Approach
RadioGraphics, March 1, 2007; 27(2): 431 - 454.
[Abstract] [Full Text] [PDF]

Home page
 ImagingHome page
A SLATER
Alteration in bowel habit
Imaging, December 1, 2006; 18(4): 208 - 217.
[Abstract] [Full Text] [PDF]

Home page
 RadioGraphicsHome page
A. C. Silva, E. A. Vens, A. K. Hara, J. G. Fletcher, J. L. Fidler, and C. D. Johnson
Evaluation of Benign and Malignant Rectal Lesions with CT Colonography and Endoscopic Correlation.
RadioGraphics, July 1, 2006; 26(4): 1085 - 1099.
[Abstract] [Full Text] [PDF]

Home page
 The Annals of PharmacotherapyHome page
C. Hur, A. T Chan, A. C Tramontano, and G S. Gazelle
Coxibs Versus Combination NSAID and PPI Therapy for Chronic Pain: An Exploration of the Risks, Benefits, and Costs
Ann. Pharmacother., June 1, 2006; 40(6): 1052 - 1063.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
R. L. MacCarty, C. D. Johnson, J. G. Fletcher, and L. A. Wilson
Occult Colorectal Polyps on CT Colonography: Implications for Surveillance.
Am. J. Roentgenol., May 1, 2006; 186(5): 1380 - 1383.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
J. C. Chen and A. H. Dachman
Cecal Mobility: A Potential Pitfall of CT Colonography.
Am. J. Roentgenol., April 1, 2006; 186(4): 1086 - 1089.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
S. Halligan, D. G. Altman, S. A. Taylor, S. Mallett, J. J. Deeks, C. I. Bartram, and W. Atkin
CT Colonography in the Detection of Colorectal Polyps and Cancer: Systematic Review, Meta-Analysis, and Proposed Minimum Data Set for Study Level Reporting
Radiology, December 1, 2005; 237(3): 893 - 904.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
R. Iannaccone, C. Catalano, F. Mangiapane, T. Murakami, A. Lamazza, E. Fiori, A. Schillaci, D. Marin, I. Nofroni, M. Hori, et al.
Colorectal Polyps: Detection with Low-Dose Multi-Detector Row Helical CT Colonography versus Two Sequential Colonoscopies
Radiology, December 1, 2005; 237(3): 927 - 937.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
T. G. Mang, C. Schaefer-Prokop, A. Maier, E. Schober, G. Lechner, and M. Prokop
Detectability of Small and Flat Polyps in MDCT Colonography Using 2D and 3D Imaging Tools: Results from a Phantom Study
Am. J. Roentgenol., December 1, 2005; 185(6): 1582 - 1589.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
M. Macari and E. J. Bini
CT Colonography: Where Have We Been and Where Are We Going?
Radiology, December 1, 2005; 237(3): 819 - 833.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
J. A. Soto, M. A. Barish, and J. Yee
Reader Training in CT Colonography: How Much Is Enough?
Radiology, October 1, 2005; 237(1): 26 - 27.
[Full Text] [PDF]

Home page
 RadiologyHome page
S. H. Park, H. K. Ha, M.-J. Kim, K. W. Kim, A. Y. Kim, D. H. Yang, M.-G. Lee, P. N. Kim, Y. M. Shin, S.-K. Yang, et al.
False-Negative Results at Multi-Detector Row CT Colonography: Multivariate Analysis of Causes for Missed Lesions
Radiology, May 1, 2005; 235(2): 495 - 502.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
B. P. Mulhall, G. R. Veerappan, and J. L. Jackson
Meta-Analysis: Computed Tomographic Colonography
Ann Intern Med, April 19, 2005; 142(8): 635 - 650.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
J. T. Ferrucci
Colonoscopy: Virtual and Optical--Another Look, Another View
Radiology, April 1, 2005; 235(1): 13 - 16.
[Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
A. Ozgun, E. Rollven, L. Blomqvist, S. Bremmer, R. Odh, and A. Fransson
Polyp Detection with MDCT: A Phantom-Based Evaluation of the Impact of Dose and Spatial Resolution
Am. J. Roentgenol., April 1, 2005; 184(4): 1181 - 1188.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
M. A. Barish, J. A. Soto, and J. T. Ferrucci
Consensus on Current Clinical Practice of Virtual Colonoscopy
Am. J. Roentgenol., March 1, 2005; 184(3): 786 - 792.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
D. J. Chung, K. C. Huh, W. J. Choi, and J. K. Kim
CT Colonography Using 16-MDCT in the Evaluation of Colorectal Cancer
Am. J. Roentgenol., January 1, 2005; 184(1): 98 - 103.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
L Bogoni, P Cathier, M Dundar, A Jerebko, S Lakare, J Liang, S Periaswamy, M E Baker, and M Macari
Computer-aided detection (CAD) for CT colonography: a tool to address a growing need
Br. J. Radiol., January 1, 2005; 78(suppl_1): S57 - S62.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
M. Cohnen, C. Vogt, A. Beck, K. Andersen, W. Heinen, S. vom Dahl, V. Aurich, D. Haeussinger, and U. Moedder
Feasibility of MDCT Colonography in Ultra-Low-Dose Technique in the Detection of Colorectal Lesions: Comparison with High-Resolution Video Colonoscopy
Am. J. Roentgenol., November 1, 2004; 183(5): 1355 - 1359.
[Abstract] [Full Text] [PDF]

Home page
 RadioGraphicsHome page
J. Yee, S. D. Wall, and P. J. Pickhardt
Invited Commentary * Author's Response
RadioGraphics, November 1, 2004; 24(6): 1557 - 1559.
[Full Text] [PDF]

Home page
 RadiologyHome page
R. E. van Gelder, H. W. Venema, J. Florie, C. Y. Nio, I. W. O. Serlie, M. P. Schutter, J. C. van Rijn, F. M. Vos, A. S. Glas, P. M. M. Bossuyt, et al.
CT Colonography: Feasibility of Substantial Dose Reduction--Comparison of Medium to Very Low Doses in Identical Patients
Radiology, August 1, 2004; 232(2): 611 - 620.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
M. Macari, E. J. Bini, S. L. Jacobs, Y. W. Lui, S. Laks, A. Milano, and J. Babb
Significance of Missed Polyps at CT Colonography
Am. J. Roentgenol., July 1, 2004; 183(1): 127 - 134.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
S. Laks, M. Macari, and E. J. Bini
Positional Change in Colon Polyps at CT Colonography
Radiology, June 1, 2004; 231(3): 761 - 766.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
P. B. Cotton, V. L. Durkalski, B. C. Pineau, Y. Y. Palesch, P. D. Mauldin, B. Hoffman, D. J. Vining, W. C. Small, J. Affronti, D. Rex, et al.
Computed Tomographic Colonography (Virtual Colonoscopy): A Multicenter Comparison With Standard Colonoscopy for Detection of Colorectal Neoplasia
JAMA, April 14, 2004; 291(14): 1713 - 1719.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
T. M. Gluecker, J. G. Fletcher, T. J. Welch, R. L. MacCarty, W. S. Harmsen, J. R. Harrington, D. Ilstrup, L. A. Wilson, K. E. Corcoran, and C. D. Johnson
Characterization of Lesions Missed on Interpretation of CT Colonography Using a 2D Search Method
Am. J. Roentgenol., April 1, 2004; 182(4): 881 - 889.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
M. Macari, E. J. Bini, S. L. Jacobs, S. Naik, Y. W. Lui, A. Milano, R. Rajapaksa, A. J. Megibow, and J. Babb
Colorectal Polyps and Cancers in Asymptomatic Average-Risk Patients: Evaluation with CT Colonography
Radiology, March 1, 2004; 230(3): 629 - 636.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
H-W Chen, S-J Chen, and I-S Chiu
Computed tomographic virtual cardioscopy in a case of left atrial myxoma
Heart, February 1, 2004; 90(2): e8 - 8.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
A. H. Dachman and M. E. Zalis
Quality and Consistency in CT Colonography and Research Reporting
Radiology, February 1, 2004; 230(2): 319 - 323.
[Full Text] [PDF]

Home page
 RadiologyHome page
J. T. Edwards, R. M. Mendelson, L. Fritschi, N. M. Foster, C. Wood, D. Murray, and G. M. Forbes
Colorectal Neoplasia Screening with CT Colonography in Average-Risk Asymptomatic Subjects: Community-based Study
Radiology, February 1, 2004; 230(2): 459 - 464.
[Abstract] [Full Text] [PDF]

Home page
 RadioGraphicsHome page
R. W. F. Geenen, S. M. Hussain, F. Cademartiri, J.-W. Poley, P. D. Siersema, and G. P. Krestin
CT and MR Colonography: Scanning Techniques, Postprocessing, and Emphasis on Polyp Detection
RadioGraphics, January 1, 2004; 24(1): e18 - e18.
[Abstract] [Full Text]

Home page
 GutHome page
H Herfarth and A G Schreyer
The virtuosity of virtuality or how real is virtual colonography
Gut, December 1, 2003; 52(12): 1662 - 1664.
[Full Text] [PDF]

Home page
 GutHome page
B Ginnerup Pedersen, M Rosenkilde, T E M Christiansen, and S Laurberg
Extracolonic findings at computed tomography colonography are a challenge
Gut, December 1, 2003; 52(12): 1744 - 1747.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
R. Iannaccone, A. Laghi, C. Catalano, J. A. Brink, F. Mangiapane, S. Trenna, F. Piacentini, and R. Passariello
Detection of Colorectal Lesions: Lower-Dose Multi-Detector Row Helical CT Colonography Compared with Conventional Colonoscopy
Radiology, December 1, 2003; 229(3): 775 - 781.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
P. J. Pickhardt
Three-Dimensional Endoluminal CT Colonography (Virtual Colonoscopy): Comparison of Three Commercially Available Systems
Am. J. Roentgenol., December 1, 2003; 181(6): 1599 - 1606.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
Y. W. Lui, M. Macari, G. Israel, E. J. Bini, H. Wang, and J. Babb
CT Colonography Data Interpretation: Effect of Different Section Thicknesses--Preliminary Observations
Radiology, December 1, 2003; 229(3): 791 - 797.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
S. A. Taylor, S. Halligan, B. P. Saunders, P. Bassett, M. Vance, and C. I. Bartram
Acceptance by Patients of Multidetector CT Colonography Compared with Barium Enema Examinations, Flexible Sigmoidoscopy, and Colonoscopy
Am. J. Roentgenol., October 1, 2003; 181(4): 913 - 921.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
J. T. Ferrucci
Virtual Colonoscopy for Colon Cancer Screening: Further Reflections on Polyps and Politics
Am. J. Roentgenol., September 1, 2003; 181(3): 795 - 797.
[Full Text] [PDF]

Home page
 RadioGraphicsHome page
M. Macari, E. J. Bini, S. L. Jacobs, N. Lange, and Y. W. Lui
Filling Defects at CT Colonography: Pseudo- and Diminutive Lesions (The Good), Polyps (The Bad), Flat Lesions, Masses, and Carcinomas (The Ugly)
RadioGraphics, September 1, 2003; 23(5): 1073 - 1091.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
L. Berlin
Potential Legal Ramifications of Whole-Body CT Screening: Taking a Peek into Pandora's Box
Am. J. Roentgenol., February 1, 2003; 180(2): 317 - 322.
[Full Text] [PDF]

Home page
 RadiologyHome page
E. G. McFarland, T. K. Pilgram, J. A. Brink, R. A. McDermott, C. V. Santillan, P. W. Brady, J. P. Heiken, D. M. Balfe, L. B. Weinstock, E. P. Thyssen, et al.
CT Colonography: Multiobserver Diagnostic Performance
Radiology, November 1, 2002; 225(2): 380 - 390.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
RADIOLOGY RADIOGRAPHICS RSNA JOURNALS ONLINE
Copyright © 2002 by the Radiological Society of North America.