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Published online before print August 16, 2002, 10.1148/radiol.2251011292

(Radiology 2002;225:43.)

A more recent version of this article appeared on October 1, 2002
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© RSNA, 2002

Vascular and Interventional Radiology

Time-resolved Three-dimensional Contrast-enhanced MR Angiography of the Peripheral Vessels1

J. Shannon Swan, MD2, Timothy J. Carroll, PhD, Todd W. Kennell, MD, Dennis M. Heisey, PhD, Frank R. Korosec, PhD, Richard Frayne, PhD3, Charles A. Mistretta, PhD and Thomas M. Grist, MD

1 From the Depts of Radiology (J.S.S., T.W.K., F.R.K., R.F., T.M.G.), Med Physics (T.J.C., F.R.K., R.F., C.A.M., T.M.G.), and Surgery (D.M.H.), Univ of Wisconsin-Madison Med School, Wis. Received Jul 27, 2001; revision requested Sep 4; revision received Dec 19; accepted Feb 19, 2002. Supported by NIH R01 HL51370 and Nycomed-Amersham. Address correspondence to T.J.C., Depts of Radiology and Biomedical Engineering, Northwestern University, 448 E Ontario St, Ste 700, Chicago, IL 60611 (e-mail: t-carroll@northwestern.edu).

PURPOSE: To compare the diagnostic accuracy of time-resolved three-dimensional contrast material–enhanced magnetic resonance (MR) angiography with that of conventional angiography for imaging the lower extremity vasculature.

MATERIALS AND METHODS: Sixty-nine patients who were evaluated for possible surgical intervention underwent conventional angiography (ie, digital subtraction angiography [DSA]) and contrast-enhanced MR angiography (ie, time-resolved imaging of contrast kinetics [TRICKS]). Two independent, blinded readers evaluated vessel stenosis and occlusion at DSA and MR angiographic image readings. Sensitivity, specificity, positive and negative predictive values, and area under the receiver operating characteristic curve were analyzed with repeated-measures analysis of variance. The Cohen {kappa} test was performed to examine interreader variability.

RESULTS: At pooled readings, contrast-enhanced MR angiography had a sensitivity of 78% and a specificity of 98% for detection of occlusion. For detection of significant stenosis (at least one >=50% stenosis), sensitivity and specificity were 77% and 91%, respectively. Interreader agreement was high for detection of both occlusion ({kappa} = 0.76) and significant stenosis ({kappa} = 0.68). Sensitivity increased as MR angiographic technical parameters were optimized. When improvements resulting from coil type and injection protocol were considered, the sensitivity and specificity of TRICKS MR angiography were 89% and 97%, respectively, for occlusion detection and 87% and 90%, respectively, for significant stenosis detection.

CONCLUSION: Contrast-enhanced TRICKS MR angiography is a feasible and minimally invasive means of acquiring angiograms of the peripheral vasculature with high sensitivity and specificity.

© RSNA, 2002

Index terms: Angiography, comparative studies, 92.122, 92.12942, 92.12943, 98.122, 98.12942, 98.12943 • Arteries, stenosis or obstruction, 92.721, 98.721 • Extremities, angiography, 92.122, 92.12942, 92.12943, 98.122, 98.12942, 98.12943 • Magnetic resonance (MR), vascular studies, 92.12942, 92.12943, 98.12942, 98.12943




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