HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text All Versions of this Article: 2252011325v1 225/2/487    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nahrendorf, M. Articles by Bauer, W. R. Search for Related Content PubMed PubMed Citation Articles by Nahrendorf, M. Articles by Bauer, W. R.

Effect of Transmyocardial Laser Revascularization on Myocardial Perfusion and Left Ventricular Remodeling after Myocardial Infarction in Rats¹

¹ From the Physikalisches Institut (EP5) (M.N., K.H.H., A.H.) and Medizinische Universitätsklinik (K.H., C.W., R.K., G.E., W.R.B.), Universität Würzburg, Josef Schneider-Strasse 2, 97080 Würzburg, Germany; and Medizinisches Laserzentrum Lübeck, Germany (D.T., R.B.). Received August 6, 2001; revision requested September 24; final revision received March 18, 2002; accepted April 1. Supported by Sonderforschungsbereich 355 Herzinsuffizienz and Graduiertenkolleg HA 1232/8-1. Address correspondence to W.R.B. (e-mail: w.bauer@medizin.uni-wuerzburg.de).

PURPOSE: To monitor perfusion changes in remote myocardium caused by transmyocardial laser revascularization (TMLR) and to investigate the influence of TMLR on left ventricular morphology and function.

MATERIALS AND METHODS: The coronary arteries were ligated in 32 Wistar rats. Eight weeks later, cine magnetic resonance (MR) imaging was performed in both the treatment (n = 12) and control group (n = 8). TMLR was then performed in the remote myocardium in the treated group. Twelve weeks after myocardial infarction, cine MR imaging, including dobutamine-induced (10 µg per kilogram of body weight per minute via the tail vein) stress, was repeated and followed with hemodynamic measurements in both groups and with perfusion MR imaging (in-plane resolution, 140 x 140 µm) of the isolated heart at rest and during nitroglycerin-induced stress in the TMLR group (n = 10).

RESULTS: Left ventricular dilatation and hypertrophy were enhanced in the TMLR group (change in end-diastolic volume at 8–12 weeks: control group, 24.6 µL ± 16.7 and TMLR group, 81.7 µL ± 15.7; change in left ventricular mass: control group, 54.5 mg ± 19.2 and TMLR group, 124.1 mg ± 30.7; P < .03 for both). Ejection fractions at rest were approximately equal (control group, 40% ± 2; TMLR group, 38% ± 2; P value not significant), but during dobutamine-induced stress, the ejection fraction was higher in the TMLR group (54.4% ± 4.9; control group, 47.4% ± 4.8; P < .05). TMLR-treated areas were better perfused than was untreated myocardium (difference in perfusion: TMLR-treated vs control region, 3.89 mL/min/g ± 0.83 at rest vs 2.29 mL/min/g ± 1.06 during nitroglycerin-induced stress; P < .05 for both). Hemodynamic measurements revealed no differences between groups.

CONCLUSION: High-spatial-resolution perfusion MR imaging depicted a significant perfusion improvement after TMLR. Post–myocardial infarction remodeling of the left ventricle was found to be enhanced.

© RSNA, 2002

Index terms: Animals • Experimental study • Heart, experimental studies, 511.129 • Heart, MR, 51.121412 • Heart, perfusion • Lasers • Myocardium, infarction, 511.771

This article has been cited by other articles:

				P. G. Carlier and D. Bertoldi In vivo functional NMR imaging of resistance artery control Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1028 - H1036. [Abstract] [Full Text] [PDF]