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Breast MR Imaging in Women at Increased Lifetime Risk of Breast Cancer: Clinical System for Computerized Assessment of Breast Lesions—Initial Results¹

¹ From the Departments of Radiology (K.G.A.G., E.E.D., S.H.M., L.J.S.K.) and Pathology (J.L.P.), The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. From the 2000 RSNA scientific assembly. Received September 25, 2001; revision requested December 10; revision received March 1, 2002; accepted April 2. Address correspondence to K.G.A.G.

The authors developed a clinical system for computerized delineation, rating, and classification of breast lesions depicted in contrast material–enhanced magnetic resonance images obtained in women with increased lifetime risk of breast cancer. Initial results showed negative predictive values above 98% at 50% positive predictive value with negligible interoperator differences. The system demonstrated potential to help exclude malignancy with high confidence and reproducibility with a positive predictive value that is acceptable in screening.

© RSNA, 2002

Index terms: Breast, MR, 00.121412, 00.12143 • Breast neoplasms, diagnosis, 00.30, 00.311, 00.32 • Breast neoplasms, MR, 00.121412, 00.12143 • Cancer screening • Genes and genetics

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