HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text All Versions of this Article: 2263011473v1 226/3/739    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lee, S. S. Articles by Lim, T.-H. Search for Related Content PubMed PubMed Citation Articles by Lee, S. S. Articles by Lim, T.-H.

MR Imaging of Reperfused Myocardial Infarction: Comparison of Necrosis-Specific and Intravascular Contrast Agents in a Cat Model¹

¹ From the Departments of Radiology (S.S.L., H.W.G., S.B.P., J.B.S., T.H.L.) and Diagnostic Pathology (G.G.), Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap-Dong, Songpa-Ku, Seoul 138-736, Korea; and Department of Radiology, Hanseo University, Seosan, Korea (C.H.L.). Received September 4, 2001; revision requested November 7; final revision received June 3, 2002; accepted July 16. Supported by a research grant (HMP-98-G-1-028) from the Korean Health and Welfare Ministry. Address correspondence to T.H.L. (e-mail: thlim@www.amc.seoul.kr).

PURPOSE: To compare T2-weighted and Gadomer-17– and bis-gadolinium mesoporphyrins–enhanced magnetic resonance (MR) images for distinguishing reversibly from irreversibly damaged myocardium in a cat model of reperfused myocardial infarction.

MATERIALS AND METHODS: Twelve cats underwent 90 minutes of occlusion and 90 minutes of reperfusion of the left anterior descending coronary artery. After baseline T1- and T2-weighted MR images were obtained, Gadomer-17–enhanced and bis-gadolinium mesoporphyrins–enhanced T1-weighted images were sequentially obtained for 6 hours and 2 hours, respectively. After MR imaging, all cats were sacrificed for 2,3,5-triphenyltetrazolium chloride (TTC) histochemical tissue staining. Areas of abnormal signal intensity on T2-weighted and Gadomer-17–enhanced and bis-gadolinium mesoporphyrins–enhanced T1-weighted MR images were compared with the areas of infarction seen at TTC histochemical staining by using repeated-measures two-way analysis of variance, linear regression analysis, and Bland-Altman analysis.

RESULTS: Mean areas of abnormally high signal intensity on T2-weighted and Gadomer-17–enhanced T1-weighted MR images (43.9% of the left ventricular surface area ± 11.9 [SD] and 37.7% ± 10.1, respectively) were significantly larger than the mean area of myocardial infarction at TTC staining (25.7% ± 12.5) (P < .001). However, there was excellent correlation between the size of an enhancing area on bis-gadolinium mesoporphyrins–enhanced T1-weighted MR images and that of myocardial infarction at TTC staining (r = 0.916, P < .001).

CONCLUSION: bis-Gadolinium mesoporphyrins–enhanced T1-weighted MR images accurately reflect the area of infarction, whereas the size of infarction is overestimated on T2-weighted and Gadomer-17–enhanced T1-weighted MR images, which seem to depict the periinfarct area as well as the infarct area.

© RSNA, 2003

Index terms: Animals • Contrast media, experimental studies • Magnetic resonance (MR), contrast media • Myocardium, infarction, 511.771 • Myocardium, MR, 511.12143

This article has been cited by other articles:

				M. G. Friedrich, H. Abdel-Aty, A. Taylor, J. Schulz-Menger, D. Messroghli, and R. Dietz The salvaged area at risk in reperfused acute myocardial infarction as visualized by cardiovascular magnetic resonance. J. Am. Coll. Cardiol., April 22, 2008; 51(16): 1581 - 1587. [Abstract] [Full Text] [PDF]

				M. Dewey, M. Laule, M. Taupitz, N. Kaufels, B. Hamm, and D. Kivelitz Myocardial Viability: Assessment with Three-dimensional MR Imaging in Pigs and Patients Radiology, June 1, 2006; 239(3): 703 - 709. [Abstract] [Full Text] [PDF]

				T. C. Lauenstein, W. Ajaj, B. Narin, S. C. Gohde, K. Kroger, J. F. Debatin, and S. G. Ruhm MR Imaging of Apparent Small-Bowel Perfusion for Diagnosing Mesenteric Ischemia: Feasibility Study Radiology, February 1, 2005; 234(2): 569 - 575. [Abstract] [Full Text] [PDF]

				R. R. Edelman Contrast-enhanced MR Imaging of the Heart: Overview of the Literature Radiology, September 1, 2004; 232(3): 653 - 668. [Abstract] [Full Text] [PDF]

				Y. Ni, S. Dymarkowski, F. Chen, J. Bogaert, G. Marchal, T.-H. Lim, and S. S. Lee Proper Handling of Research with Invalid Conclusions [letter] * Drs Lim and Lee respond: Radiology, November 1, 2003; 229(2): 608 - 610. [Full Text] [PDF]