HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text All Versions of this Article: 2263011970v1 226/3/880    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tombach, B. Articles by Sorensen, A. G. Search for Related Content PubMed PubMed Citation Articles by Tombach, B. Articles by Sorensen, A. G.

Do Highly Concentrated Gadolinium Chelates Improve MR Brain Perfusion Imaging? Intraindividually Controlled Randomized Crossover Concentration Comparison Study of 0.5 versus 1.0 mol/L Gadobutrol¹

¹ From the Dept of Clinical Radiology, Univ of Münster, Albert-Schweitzer-Strasse 33, D-48129 Münster, Germany (B.T., E.M.F.); Dept of Radiology/Nuclear Magnetic Resonance Center, Massachusetts General Hosp, Boston (T.B., A.G.S.); Dept of Radiology, Karlsruhe, Academic Teaching Hosp of Freiburg, Germany (P.R.); Dept of Radiology, Institute of Neuroradiology, Bezirksklinikum Regensburg, Germany (G.S.); and Schering, Berlin, Germany (V.G., T.W.). Received Dec 3, 2001; revision requested Jan 18, 2002; revision received May 20; accepted Jul 1. Supported in part by Schering, Berlin, Germany. A.G.S. supported in part by grant PHS RO1NS38477. Address correspondence to B.T. (e-mail: tombach@uni-muenster.de).

PURPOSE: To assess the potential advantages of using a 1.0 mol/L versus 0.5 mol/L gadobutrol formulation for magnetic resonance (MR) brain perfusion imaging.

MATERIALS AND METHODS: Forty-three healthy volunteers were enrolled in an intraindividually controlled, randomized crossover comparison study. Two gadobutrol formulations—0.5 and 1.0 mol/L— were randomly injected during two separate treatment periods. For intraindividual comparison of effectiveness parameters, single-section gradient-echo brain perfusion MR imaging was performed under identical conditions for both investigations. Quantitative and qualitative evaluations were performed. Differences between the two gadobutrol formulations were evaluated at analysis of covariance and tested for statistical significance (P < .05) with a t test.

RESULTS: Use of 1.0 mol/L gadobutrol resulted in a significantly smaller bolus width at half maximum signal intensity decrease, a smaller mean peak time, a higher contrast and contrast-to-noise ratio between gray and white matter, and significant increases in both maximum change in transverse relaxation rate (R2_max) and differences in peak enhancement in gray matter among all volunteers (P < .001). In white matter, increases in R2_max (P = .262) and in differences in peak enhancement (P = .262) were smaller and not significant (P = .292). Parameter map analysis revealed improved quality and superior contrast in relative regional cerebral blood flow (P = .034) and mean transit time (P < .001). The lack of difference regarding relative regional cerebral blood volume maps was consistent with the use of the same dose of each gadobutrol formulation.

CONCLUSION: Brain perfusion images obtained with 1.0 mol/L gadobutrol were superior to those obtained with 0.5 mol/L gadobutrol in healthy volunteers examined with the described MR imaging protocol.

© RSNA, 2003

Index terms: Brain, MR, 10.121411, 10.121412, 10.12142, 10.12143, 10.12144 • Contrast media, comparative studies • Gadolinium • Magnetic resonance (MR), contrast media, 13.12143, 14.12143, 15.12143

This article has been cited by other articles:

				M Fenchel, A Franow, P Martirosian, M Engels, U Kramer, N I Stauder, U Helber, H Vogler, C D Claussen, and S Miller 1 M Gd-chelate (gadobutrol) for multislice first-pass magnetic resonance myocardial perfusion imaging Br. J. Radiol., November 1, 2007; 80(959): 884 - 892. [Abstract] [Full Text] [PDF]

				C W Ryu, D H Lee, H S Kim, J H Lee, C G Choi, S J Kim, and D C Suh Acquisition of MR perfusion images and contrast-enhanced MR angiography in acute ischaemic stroke patients: which procedure should be done first? Br. J. Radiol., December 1, 2006; 79(948): 962 - 967. [Abstract] [Full Text] [PDF]

				J. T. Kielstein, F. Donnerstag, S. Gasper, J. Menne, A. Kielstein, J. Martens-Lobenhoffer, F. Scalera, J. P. Cooke, D. Fliser, and S. M. Bode-Boger ADMA Increases Arterial Stiffness and Decreases Cerebral Blood Flow in Humans Stroke, August 1, 2006; 37(8): 2024 - 2029. [Abstract] [Full Text] [PDF]

				C. Manka, F. Traber, J. Gieseke, H. H. Schild, and C. K. Kuhl Three-dimensional Dynamic Susceptibility-weighted Perfusion MR Imaging at 3.0 T: Feasibility and Contrast Agent Dose Radiology, March 1, 2005; 234(3): 869 - 877. [Abstract] [Full Text] [PDF]