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Distal Airways in Humans: Dynamic Hyperpolarized ³He MR Imaging—Feasibility¹

¹ From the Department of Radiology, Brigham and Women’s Hospital, 221 Longwood Ave, Boston, MA 02115. Received January 10, 2002; revision requested March 4; final revision received August 8; accepted August 21. Address correspondence to M.S.A. (e-mail: malbert@bwh.harvard.edu).

Dynamic hyperpolarized helium 3 (³He) magnetic resonance (MR) imaging of the human airways is achieved by using a fast gradient-echo pulse sequence during inhalation. The resulting dynamic images show differential contrast enhancement of both distal airways and the lung periphery, unlike static hyperpolarized ³He MR images on which only the lung periphery is seen. With this technique, up to seventh-generation airway branching can be visualized.

© RSNA, 2003

Index terms: Bronchi, 60.92 • Helium • Lung, anatomy, 60.92 • Lung, MR, 60.12143 • Magnetic resonance (MR), contrast enhancement, 60.121412, 61.12143 • Magnetic resonance (MR), nuclei other than H, 60.121412, 60.12147

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