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Vascular and Interventional Radiology |
1 From the Mallinckrodt Institute of Radiology, Washington University Medical Center, 510 S Kingshighway Blvd, St Louis, MO 63110-1076. From the 2001 RSNA scientific assembly. Received November 23, 2001; revision requested February 12, 2002; final revision received October 28; accepted October 31. Address correspondence to L.A.G. (e-mail: gilulal@mir.wustl.edu).
PURPOSE: To evaluate different types of polymethylmethacrylate (PMMA) leakage and patient-related factors in relation to clinical midterm (1–24-month) outcome after vertebroplasty.
MATERIALS AND METHODS: Standardized four-view radiographs obtained during 363 vertebroplasties in 181 treatment sessions in 152 patients were reviewed (121 patients with osteoporotic fractures, 30 with malignant disease, and one with hemangioma). Four types of PMMA leakage and other potential predictors (patient age and sex, treated region, number of vertebral levels injected, preprocedural pain, PMMA volume per vertebra) were related to postprocedural pain response and midterm outcome after vertebroplasty. 
2 and Kruskal-Wallis tests were used for statistical analysis. The mean follow-up period was 8.8 months (range, 1–24 months).
RESULTS: At the time of discharge after the procedure, pain was absent after 106 of the 181 sessions (58.5%), better after 50 (27.6%), and the same after 25 (13.8%). In 258 of the 363 treated vertebral levels, at least one type of leakage was found. None of the evaluated factors were related significantly to postprocedural pain response, including PMMA leakage. Pain response at midterm outcome was strongly related to postprocedural treatment success, however (P < .001).
CONCLUSION: Small to moderate amounts of PMMA may escape from the vertebral body with no significant effect on therapeutic success. Immediate postprocedural pain relief is the best predictor of midterm clinical outcome after vertebroplasty.
© RSNA, 2003
Index terms: Interventional procedures, complications, 30.1267 • Osteoporosis, 30.56 • Spine, diseases, 30.33, 30.362, 30.56 • Spine, fractures, 30.41 • Spine, interventional procedures, 30.1267 • Spine, secondary neoplasms, 30.33 • Spine, vertebroplasty, 30.1267
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