HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text All Versions of this Article: 2281010683v1 228/1/185    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wenserski, F. Articles by Arendt, G. Search for Related Content PubMed PubMed Citation Articles by Wenserski, F. Articles by Arendt, G.

Human Immmunodeficiency Virus 1–associated Minor Motor Disorders: Perfusion-weighted MR Imaging and ¹H MR Spectroscopy¹

¹ From the Departments of Diagnostic Radiology (F.W., H.J.W., A.A.) and Neurology (H.J.v.G., G.A.), Heinrich-Heine-University, Moorenstr 5, 40225 Duesseldorf, Germany. Received October 15, 2001; revision requested January 8, 2002; final revision received October 11; accepted October 31. Address correspondence to F.W. (e-mail: wensersk@uni-duesseldorf.de).

PURPOSE: To investigate whether advanced magnetic resonance (MR) imaging techniques such as diffusion-weighted (DW) and perfusion-weighted (PW) MR imaging and hydrogen 1 (¹H) MR spectroscopy can depict functional and pathophysiologic mechanisms in patients who have minor motor deficits (MMDs) associated with human immunodeficiency virus 1 (HIV-1).

MATERIALS AND METHODS: Thirty-two patients with results seropositive for HIV-1 and different degrees of HIV-1–related MMD underwent conventional brain MR imaging, as well as DW and PW MR imaging and ¹H MR spectroscopy of the basal ganglia. PW MR imaging data were computed pixel by pixel for creation of time-to-peak, relative regional cerebral blood volume, and bolus amplitude parameter maps. In addition, quantitative regional cerebral blood flow (rCBF) maps were calculated with respect to the arterial input function by using the singular value decomposition algorithm. For ¹H MR spectrocopy, a stimulated echo acquisition mode 20, or STEAM 20, sequence was used. Spectra were fit for determination of the signal intensities of the different metabolites. According to psychomotor testing results, patients were divided into three groups: group 1, 10 patients with normal motor function; group 2, eight patients with psychomotor slowing for the first time; and group 3, 14 patients who had had sustained pathologic psychomotor slowing for at least 6 months before the MR imaging examination.

RESULTS: No patients had an abnormality at either conventional or DW MR imaging. PW MR imaging depicted significantly elevated rCBF in group 2 patients (P = .039, analysis of variance [ANOVA]) and significantly elevated myo-inositol–to-creatine ratio levels in group 3 patients (P = .020, ANOVA).

CONCLUSION: Quantitative PW MR imaging and ¹H MR spectroscopy can depict pathologic changes in patients who have HIV-1–related MMD but normal clinical examination and conventional MR imaging findings.

© RSNA, 2003

Index terms: Acquired immunodeficiency syndrome (AIDS), 13.2068 • Brain, MR, 13.121411, 13.121412, 13.121413, 13.121416, 13.12143, 13.12144, 13.12145 • Magnetic resonance (MR), diffusion study, 13.12144 • Magnetic resonance (MR), perfusion study, 13.12144 • Magnetic resonance (MR), spectroscopy, 13.12145

This article has been cited by other articles:

				A. B. Ragin, P. Storey, B. A. Cohen, R. R. Edelman, and L. G. Epstein Disease burden in HIV-associated cognitive impairment: A study of whole-brain imaging measures Neurology, December 28, 2004; 63(12): 2293 - 2297. [Abstract] [Full Text] [PDF]