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1 From the Departments of Radiology (Y.K., S.P.P., C.B.S., B.G., W.W., R.F.M.) and Surgery (S.R.S.), University of California, San Diego Medical Center, 200 W Arbor Dr, Dept 8756, San Diego, CA 92103-8756. From the 1999 RSNA scientific assembly. Received April 1, 2002; revision requested June 13; final revision received March 4, 2003; accepted May 19. Address correspondence to Y.K. (e-mail: ykono@ucsd.edu).
B-mode ultrasonographic (US) angiography enhanced with a microbubble-based US contrast agent (FS069) was evaluated in human subjects with carotid artery disease. Results at contrast material–enhanced US angiography and duplex US were compared with those at conventional angiography. Both US angiography and duplex US accurately depicted stenoses of 70% or more compared with those depicted at conventional angiography. The percentage diameter stenosis of the internal carotid artery measured at US angiography strongly correlated with that measured at conventional angiography (r = 0.988). The percentage area stenosis measured at US angiography strongly correlated with ex vivo measurements of the resected carotid plaque at magnetic resonance imaging (r = 0.979). US angiography depicted unsuspected wall irregularities, ulceration, and dissection.
© RSNA, 2003
Index terms: Carotid arteries, stenosis or obstruction, 172.721 • Carotid arteries, US, 172.12984, 172.12988 • Ultrasound (US), contrast media, 172.12984, 172.12988
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