HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text All Versions of this Article: 2333031658v1 233/3/905    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chen, F. Articles by Ni, Y. Search for Related Content PubMed PubMed Citation Articles by Chen, F. Articles by Ni, Y.

Visualization of Stroke with Clinical MR Imagers in Rats: A Feasibility Study¹

¹ From the Departments of Radiology (F.C., R.P., K.C., W.C., G.M., Y.N.) and Molecular and Vascular Biology (Y.S., N.N.), University Hospitals, K. U. Leuven, Herestraat 49, B-3000 Leuven, Belgium. Received October 13, 2003; revision requested January 7, 2004; revision received February 6; accepted March 2. Address correspondence to Y.N. (e-mail: yicheng.ni@med.kuleuven.ac.be).

This experiment was conducted in compliance with the guidelines of the International Committee on Thrombosis and Hemostasis and the current institutional regulations for use and care of laboratory animals. The purpose of the present study was to report the feasibility of using clinical magnetic resonance (MR) imaging devices for depiction of stroke in a rat model. Twenty-four rats with photochemically induced thrombosis of the middle cerebral artery were examined at superacute (1 hour, n = 24), acute (12 hours, n = 12), and subacute (24 hours, n = 12) phases with 1.5-T MR imaging weighted for T1, T2, diffusion, and gadopentetate dimeglumine–enhanced perfusion. With reasonable signal-to-noise ratio and imaging times, ischemic lesions were well distinguished on MR images as validated qualitatively and quantitatively with postmortem standard-of-reference techniques, including volume-rendered computed tomography, microangiography, and histochemistry. In the superacute phase, the perfusion defect at perfusion-weighted MR imaging was well matched with microangiographic and pathologic findings (P > .05). There was no difference in lesion size at perfusion-weighted MR imaging between superacute and subacute phases (P > .05). Performance of certain stroke-related research in rats is feasible with clinical MR imagers.

© RSNA, 2004

Index terms: Animals • Magnetic resonance (MR), diffusion study • Magnetic resonance (MR), experimental studies • Magnetic resonance (MR), perfusion study

This article has been cited by other articles:

				F CHEN, Q LIU, H WANG, Y SUZUKI, N NAGAI, J YU, G MARCHAL, and Y NI Comparing two methods for assessment of perfusion-diffusion mismatch in a rodent model of ischaemic stroke: a pilot study Br. J. Radiol., March 1, 2008; 81(963): 192 - 198. [Abstract] [Full Text] [PDF]

				F. Chen, Y. Suzuki, N. Nagai, X. Sun, H. Wang, J. Yu, G. Marchal, and Y. Ni Microplasmin and Tissue Plasminogen Activator: Comparison of Therapeutic Effects in Rat Stroke Model at Multiparametric MR Imaging Radiology, August 1, 2007; 244(2): 429 - 438. [Abstract] [Full Text] [PDF]