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Feasibility of US-guided High-Intensity Focused Ultrasound Treatment in Patients with Advanced Pancreatic Cancer: Initial Experience¹

¹ From the Institute of Ultrasonic Engineering in Medicine and Clinical Center for Tumor Therapy of 2nd Affiliated Hospital, Chongqing University of Medical Sciences, 1 Medical College Road, Box 153, Chongqing 400016, China. Received June 23, 2004; revision requested August 30; revision received September 6; accepted October 4. Supported by grant 96-905-02-01 from the Ministry of Science and Technology of China and grants 39300125, 39630340, 39630340, 39670749, 39770841, 39770712, 30070217, and 30171060 from the National Natural Science Foundation of China. Address correspondence to F.W. (e-mail: mfengwu{at}yahoo.com).

The study was approved by the university ethics committee, and informed consent was obtained from all patients. The purpose of this study was to prospectively evaluate ultrasonographically guided high-intensity focused ultrasound in the treatment of patients with advanced-stage pancreatic cancer. Eight patients underwent high-intensity focused ultrasound ablation, and laboratory and radiologic examinations were performed after intervention. Changes in symptoms and survival time were noted at follow-up. No complications were observed, and preexisting severe back pain disappeared after intervention. Follow-up images revealed an absence of tumor blood supply and shrinkage of the ablated tumor. Four patients died, and four patients were alive at the time of this writing, with a median survival time of 11.25 months. The authors conclude that high-intensity focused ultrasound ablation is safe and feasible in the treatment of advanced pancreatic cancer.

© RSNA, 2005

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