HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Quicktime movies All Versions of this Article: 2363041165v1 236/3/815    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sipola, P. Articles by Kuusisto, J. Search for Related Content PubMed PubMed Citation Articles by Sipola, P. Articles by Kuusisto, J.

Cine MR Imaging of Myocardial Contractile Impairment in Patients with Hypertrophic Cardiomyopathy Attributable to Asp175Asn Mutation in the -Tropomyosin Gene¹

¹ From the Departments of Clinical Radiology (P.S., H.M.) and Medicine (P.J., M.L., K.P., J.K.), Kuopio University Hospital, Puijonlaaksontie 2, Kuopio FIN-70210, Finland; Department of Radiology, Helsinki University Central Hospital, Helsinki, Finland (K.L.); and Functional Brain Imaging Unit, Brain Research Center, Helsinki, Finland (H.J.A.). Received July 2, 2004; revision requested September 3; revision received October 19; accepted November 26. P.S. supported by Kuopio University Hospital Research grant 5063502, the Instrumentarium Scientific Foundation, the Aarne and Aili Turunen Foundation, and the Aarne Koskelo Foundation. Address correspondence to J.K. (e-mail: johanna.kuusisto{at}kuh.fi).

PURPOSE: To prospectively investigate the relationship between myocardial contractile impairment and left ventricular (LV) hypertrophy measured at cardiac magnetic resonance (MR) imaging in patients with hypertrophic cardiomyopathy (HCM) caused by the substitution of aspartic acid 175 with asparagine (ie, Asp175Asn mutation) in the -tropomyosin gene (TPM1).

MATERIALS AND METHODS: The study protocol was approved by the hospital ethics committee, and all subjects gave written informed consent. LV mass, maximal LV wall thickness, and myocardial fractional thickening during systole were measured at cine MR imaging in 24 subjects (11 male, 13 female; mean age, 42 years; age range, 17–68 years) with the Asp175Asn mutation in TPM1 and in 17 healthy volunteers (eight men, nine women; mean age, 38 years; age range, 23–60 years). The proportion of hypokinetic LV segments was calculated as the number of LV segments with fractional thickening of less than 30% divided by the total number of segments measured. Anthropometric and biochemical correlates of LV hypertrophy were determined. Univariate and multiple linear regression analyses were used to investigate the association of the proportion of hypokinetic segments and other correlates of LV hypertrophy with LV mass and maximal wall thickness.

RESULTS: The proportion of hypokinetic segments was higher in patients with HCM than in control subjects (37% ± 20 [standard deviation] vs 12% ± 12, P < .001). In stepwise multiple regression analysis, the proportion of hypokinetic segments accounted for 42% (P < .001); the LV end-diastolic volume, for 24% (P = .003); and male sex, for 10% (P = .014) of the variability in LV mass in patients with HCM. The proportion of hypokinetic LV segments, which accounted for 48% of the variability in LV maximal wall thickness (P < .001), was the only variable significantly associated with maximal wall thickness.

CONCLUSION: The extent of myocardial contractile impairment is strongly and independently related to LV mass and maximal wall thickness in patients with HCM attributable to the Asp175Asn mutation in TPM1.

Supplemental material: radiology.rsnajnls.org/cgi/content/full/2363041165/DC1

© RSNA, 2005

This article has been cited by other articles:

				M. W. Hansen and N. Merchant MRI of Hypertrophic Cardiomyopathy: Part I, MRI Appearances Am. J. Roentgenol., December 1, 2007; 189(6): 1335 - 1343. [Abstract] [Full Text] [PDF]

				S. F. Nagueh and J. J. Mahmarian Noninvasive Cardiac Imaging in Patients With Hypertrophic Cardiomyopathy J. Am. Coll. Cardiol., December 19, 2006; 48(12): 2410 - 2422. [Abstract] [Full Text] [PDF]