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Blood Vessel Morphologic Changes Depicted with MR Angiography during Treatment of Brain Metastases: A Feasibility Study¹

¹ From the Computer Assisted Surgery and Imaging Laboratory, University of North Carolina, 247 Wing E, CB 7062, Chapel Hill, NC, 27599 (E.B., J.K.S., D.Z., L.A.C., W.L., M.G.E.); and Department of Radiology, Dana-Farber/Harvard Cancer Center, Boston, Mass (N.U.L., E.P.W.). Received November 4, 2006; revision requested January 10, 2007; revision received January 30; accepted March 16; final version accepted April 16. Supported in part by the National Institute of Biomedical Imaging and Bioengineering (R01EB000219), Avon Foundation (P50CA89393-AV-55P and P50CA58185-AV-55P2), National Cancer Institute (P30CA16086-29S1, P50CA089393-05S1, and P30CA58223), National Institutes of Health (M01RR00046), and American Society of Clinical Oncology Young Investigator Award. Address correspondence to E.B. (e-mail: bullitt{at}med.unc.edu).

Purpose: To prospectively determine if magnetic resonance (MR) angiography can depict intracranial vascular morphologic changes during treatment of brain metastases from breast cancer and if serial quantitative vessel tortuosity measurements can be used to predict tumor treatment response sooner than traditional methods.

Materials and Methods: Institutional review board approval and informed consent were obtained for this HIPAA-compliant study. Twenty-two women aged 31–61 years underwent brain MR angiography prior to and 2 months after initiation of lapatinib therapy for brain metastases from breast cancer. Vessels were extracted from MR angiograms with a computer program. Changes in vessel number, radius, and tortuosity were calculated mathematically, normalized with values obtained in 34 healthy control subjects (19 women, 15 men; age range, 19–72 years), and compared with subsequent assessments of tumor volume and clinical course.

Results: All patients exhibited abnormal vessel tortuosity at baseline. Nineteen (86%) patients did not exhibit improvement in vessel tortuosity at 2-month follow-up, and all patients demonstrated tumor growth at 4-month follow-up. Vessel tortuosity measurements enabled us to correctly predict treatment failure 1–2 months earlier than did traditional methods. Three (14%) patients had quantitative improvement in vessel tortuosity at 2-month follow-up, with drop out of small abnormal vessels and straightening of large vessels. Each of the two patients for whom further follow-up data were available responded to treatment for more than 6 months.

Conclusion: Study results established the feasibility of using MR angiography to quantify vessel shape changes during therapy. Although further research is required, results suggest that changes in vessel tortuosity might enable early prediction of tumor treatment response.

© RSNA, 2007