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Pancreatic Perfusion: Noninvasive Quantitative Assessment with Dynamic Contrast-enhanced MR Imaging without and with Secretin Stimulation in Healthy Volunteers—Initial Results¹

¹ From the Departments of Radiology (M.A.B., T.M., V.D., C.M.) and Gastroenterology (J.D.), Erasme Hospital, and IRIBHN, Statistical Unit (V.D.M.), Université Libre de Bruxelles, Route de Lennik, 808, 1070 Brussels, Belgium; and Philips Medical Systems Benelux, Brussels, Belgium (V.D.). Received April 8, 2007; revision requested June 12; revision received August 29; final version accepted September 27. Address correspondence to M.A.B. (e-mail: mbali{at}ulb.ac.be).

Purpose: To prospectively quantify pancreatic regional perfusion with dynamic contrast material–enhanced magnetic resonance (MR) imaging by using a one-compartment model and to assess perfusion changes during secretin stimulation in healthy volunteers.

Materials and Methods: The study had institutional review board approval, and written informed consent was obtained. Ten healthy volunteers (five men, five women; mean age, 24.7 years ± 1.9 [standard deviation]; range, 22–29 years) underwent MR imaging pancreatic perfusion studies performed twice without secretin and twice during secretin stimulation. Dynamic contrast-enhanced MR imaging consisted of saturation-recovery T1-weighted turbo-field-echo imaging with peripheral pulse triggering and respiratory tracking. A dose of 0.05 mmol gadodiamide per kilogram of body weight was injected at a rate of 3.5 mL/sec. Regional perfusion parameters were fitted with a one-compartment model. The analysis of variance test for repeated measurements was used to assess differences in pancreatic perfusion without and that with secretin administration.

Results: Significant differences in perfusion parameters between the three pancreatic regions were observed (P < .05). During secretin stimulation, a significant difference was observed only between the body and the tail of the pancreas (P = .02). A significant increase (P = .003) in pancreatic perfusion was observed after secretin administration. Mean pancreatic perfusion was 184 mL/min/100 g of tissue ± 71, 207 mL/min/100 g ± 77, and 230 mL/min/100 g ± 87 without secretin and 342 mL/min/100 g ± 154, 338 mL/min/100 g ± 156, and 373 mL/min/100 g ± 176 after secretin stimulation in the head, body, and tail of the pancreas, respectively. Intraindividual variability was 21% without secretin stimulation and 46% with secretin stimulation.

Conclusion: Dynamic contrast-enhanced MR imaging enables noninvasive quantification of regional pancreatic perfusion in resting conditions and demonstrates the increase in pancreatic perfusion during secretin stimulation in healthy subjects.

© RSNA, 2008