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Isotropic High-Spatial-Resolution Contrast-enhanced 3.0-T MR Angiography in Patients Suspected of Having Renal Artery Stenosis¹

¹ From the Department of Diagnostic Radiology, University of Tuebingen, Hoppe-Seyler-Str 3, 72076 Tuebingen, Germany (U.K., J.W., M.C.F., A.S., G.T., C.D.C., S.M.); and Siemens Cardiovascular Center (G.L.) and Department of Radiological Sciences (J.P.F.), University of California Los Angeles, Los Angeles, Calif. Received March 28, 2007; revision requested May 23; revision received August 7; accepted August 28; final version accepted September 28. Address correspondence to U.K. (e-mail: ulrich.kramer{at}med.uni-tuebingen.de).

The purpose of this study was to prospectively evaluate the diagnostic performance of contrast material–enhanced magnetic resonance (MR) angiography performed at 3 T for assessment of renal artery stenosis (RAS) by using parallel acquisition techniques with high acceleration factors and with digital subtraction angiography (DSA) as the reference standard. The study was institutional review board approved, and written informed consent was obtained from all patients. Twenty-nine patients (18 men, 11 women; mean age, 57.1 years ± 14.3 [standard deviation]) suspected of having RAS underwent MR angiography. Images were evaluated qualitatively and quantitatively. The interobserver variability, sensitivity, specificity, and positive and negative predictive values of 3-T MR angiography, as compared with DSA (performed in 15 patients), were calculated. All examinations yielded good or excellent image quality. The sensitivity and specificity of MR angiography in grading significant (>75%) stenosis were 94% and 96%, respectively. Owing to its high sensitivity, contrast-enhanced 3-T MR angiography can be used reliably to exclude RAS and can serve as a useful screening method in the diagnostic work-up of patients with arterial hypertension.

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